Causal association between mitochondrial genes and colorectal cancer: a multi-omics Mendelian randomization study
The multi-omics approach identified several mitochondrial-related genes significantly associated with CRC risk, providing new insights into the role of mitochondrial dysfunction in CRC pathogenesis, and potentially providing further investigation and future therapeutic strategies targeting mitochondrial pathways in CRC management.
Authors
- Yonglei Zhang (ORCID: https://orcid.org/0000-0002-1452-0109)
- Wei Yang (ORCID: https://orcid.org/0000-0001-9517-7025)
- Fei Ma (ORCID: https://orcid.org/0000-0002-2967-8013)
- Fusheng Ge
- Bin Zhang (ORCID: https://orcid.org/0000-0002-6631-7647)
- Xiaobing Chen
- Zhandong Zhang
- Yawei Hua
- Shuaibing Lu
- Liangqun Peng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Zhengzhou University (CN)
- Luohe Medical College (CN)
- Henan Cancer Hospital (CN)
- Loudi Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1007/s12672-025-03699-2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Henan Province