Obesity as a Disruptor of the Pain Inhibition Response in Fibromyalgia: A Pooled Multi‐Trial Analysis of 521 Patients
This study uniquely explores the relationship between BMI and pain inhibition response in fibromyalgia patients, revealing a non-linear association and highlighting BMI's role as a moderator of CPM. The findings emphasise that obesity disrupts endogenous pain regulation, leading to more severe pain and depression symptoms. This underscores the potential for weight management in FMS treatment and supports developing personalised interventions considering obesity status.
Authors
- Wolnei Caumo
- Felipe Fregni (ORCID: https://orcid.org/0000-0002-1703-7526)
- Kevin Pacheco‐Barrios (ORCID: https://orcid.org/0000-0002-7166-2816)
- Guilherme J. M. Lacerda
- Bárbara Regina França
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidad San Ignacio de Loyola (PE)
- Spaulding Rehabilitation Hospital (US)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1002/ejp.70145
- Citations
- 1
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47