C5aR1 Inhibition Alleviates Cranial Radiation–Induced Cognitive Decline
Complement cascade activation by cranial radiotherapy for brain cancers mediates radiation-induced neuroinflammation, synaptic loss, and cognitive dysfunction that can be alleviated by inhibiting the complement C5a-C5aR1 signaling axis, providing a tractable therapeutic approach.
Authors
- Leila Alikhani (ORCID: https://orcid.org/0009-0006-7443-4823)
- Robert P. Krattli (ORCID: https://orcid.org/0000-0002-8911-5984)
- Mineh Markarian (ORCID: https://orcid.org/0000-0001-5887-6775)
- Munjal M. Acharya (ORCID: https://orcid.org/0000-0002-7767-5642)
- Richard J. Clark (ORCID: https://orcid.org/0000-0002-6807-5426)
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Trent M. Woodruff (ORCID: https://orcid.org/0000-0003-1382-911X)
- Manal T. Usmani (ORCID: https://orcid.org/0009-0007-6419-7729)
- Janet E. Baulch (ORCID: https://orcid.org/0000-0002-1078-6946)
- Sanad M. El-Khatib (ORCID: https://orcid.org/0000-0002-1697-2264)
- Arya R. Vagadia
- An H. Do
- Shreya Madan (ORCID: https://orcid.org/0009-0005-2415-7701)
Institutions
- University of California, Los Angeles (US)
- The University of Queensland (AU)
- University of California, Irvine (US)
- Irvine University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4869
- Citations
- 4
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.50