The influence of ferroptosis-associated gene HSPA5 on the prognosis and immune evasion of lung adenocarcinoma
The ferroptosis-related gene HSPA5 diminishes the effectiveness of LUAD immunotherapy by promoting immune evasion, thus serving as a potential indicator for predicting the therapeutic response. Notably, patients with lower HSPA5 expression tend to have a more favorable prognosis. Our discoveries may contribute significantly to the advancement of personalized treatment strategies and the enhancement of immunotherapy outcomes for LUAD patients.
Authors
- Xiang Gao (ORCID: https://orcid.org/0000-0001-7478-5072)
- Yanqing Wang
- Liguo Luo
- Lixin Wang (ORCID: https://orcid.org/0000-0002-5402-8557)
- Lei Xiong (ORCID: https://orcid.org/0000-0003-3799-7679)
- Yi Shen (ORCID: https://orcid.org/0000-0001-9996-646X)
- Jun Su
Institutions
- XinHua Hospital (CN)
- Jinling Institute of Technology (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1007/s12672-025-03629-2
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province