Investigating the Causal Effect of Potential Therapeutic Agents for Colorectal Cancer Prevention: A Mendelian Randomization Analysis
These findings provide updated evidence on the role of previously reported therapeutic agents in colorectal cancer risk, helping prioritize further evaluation of those agents with potential etiologic roles in cancer development.
Authors
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Amanda I. Phipps (ORCID: https://orcid.org/0000-0002-1446-2201)
- Christopher I. Li (ORCID: https://orcid.org/0000-0003-1543-0743)
- E Fryer (ORCID: https://orcid.org/0000-0001-7769-2111)
- Vı́ctor Moreno (ORCID: https://orcid.org/0000-0002-2818-5487)
- Loı̈c Le Marchand (ORCID: https://orcid.org/0000-0001-5013-980X)
- Philip Haycock (ORCID: https://orcid.org/0000-0001-5001-3350)
- Peter T. Campbell (ORCID: https://orcid.org/0000-0002-5549-2036)
- Richard Michael Martin (ORCID: https://orcid.org/0000-0002-7992-7719)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Stephanie L. Schmit (ORCID: https://orcid.org/0000-0001-5931-1194)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Robert C. Grant (ORCID: https://orcid.org/0000-0002-9821-0377)
- D. Timothy Bishop (ORCID: https://orcid.org/0000-0002-8752-8785)
Institutions
- Broad Institute (US)
- University of Hawaiʻi at Mānoa (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- University of Leeds (GB)
- Cleveland Clinic (US)
- University of Hawaii System (US)
- University of Washington (US)
- University Hospitals Bristol NHS Foundation Trust (GB)
- At Bristol (GB)
- Bellvitge University Hospital (ES)
- Princess Margaret Cancer Centre (CA)
- University of Bristol (GB)
- Cleveland Clinic Lerner College of Medicine (US)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Cancer Center of Hawaii (US)
- Institut Català d'Oncologia (ES)
- University of Washington Applied Physics Laboratory (US)
- The White House (US)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Centre international de recherche sur le cancer (FR)
- University of Hawaii Cancer Center
- Imperial College London (GB)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1158/1055-9965.epi-25-0875
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00