Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction
Our findings reveal a detailed molecular mechanism underlying the activity-dependent interplay between M<sub>1</sub> and M<sub>2</sub> mAChRs and their respective PKC isoforms, highlighting their combined roles in optimizing acetylcholine release at the NMJ.
Authors
- Carolina Silvera Simón (ORCID: https://orcid.org/0000-0001-7327-8415)
- Laia Just‐Borràs (ORCID: https://orcid.org/0000-0003-0473-3730)
- Víctor Cilleros‐Mañé (ORCID: https://orcid.org/0000-0001-5690-9932)
- María A. Lanuza (ORCID: https://orcid.org/0000-0003-4795-4103)
- Josep Tomàs (ORCID: https://orcid.org/0000-0002-0406-0006)
- Marta Tomàs (ORCID: https://orcid.org/0000-0002-4151-1697)
- Marta Balanyà-Segura (ORCID: https://orcid.org/0000-0003-0983-4944)
- Erica Hurtado (ORCID: https://orcid.org/0000-0001-8930-4462)
- А. А. Полищук (ORCID: https://orcid.org/0000-0001-6445-1538)
- Meryem Jami-ElHirchi (ORCID: https://orcid.org/0009-0004-5435-9622)
- Marina Díaz-Wallach
Institutions
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Universitat Rovira i Virgili (ES)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12964-025-02440-4
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00