Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients
Our findings revealed a complex and heterogeneous genetic background of IBC in the Tunisian population that might contribute to disease susceptibility and impact disease prognosis. The genetic features of IBC presented in this study provide valuable insights into the molecular mechanisms underlying the disease offering not only a deeper understanding within the context of Tunisia but also shedding light on its relevance to other North African populations characterized by similar epidemiological and genetic features.
Authors
- Nesrine Mejri (ORCID: https://orcid.org/0000-0001-7647-5027)
- Khalid Sadki (ORCID: https://orcid.org/0000-0002-9224-5050)
- Kais Chaabane
- Ahmed Rebaï (ORCID: https://orcid.org/0000-0002-8954-8683)
- Amal Souissi (ORCID: https://orcid.org/0000-0003-3838-1876)
- Fouzia Radouani (ORCID: https://orcid.org/0000-0002-6221-2661)
- Hana Hakim (ORCID: https://orcid.org/0000-0001-7146-5452)
- Rahma Ayadi
- Hamouda Boussen (ORCID: https://orcid.org/0000-0002-4131-8475)
- Meryem Fakhkhari (ORCID: https://orcid.org/0000-0001-8227-1549)
- Meriem Khyatti (ORCID: https://orcid.org/0000-0001-9376-4322)
- Sonia Abdelhak (ORCID: https://orcid.org/0000-0001-8466-5525)
- Yosr Hamdi (ORCID: https://orcid.org/0000-0002-2815-1834)
- Samir Aloulou
- Maha Driss (ORCID: https://orcid.org/0000-0001-8236-8746)
- Tarek Ben Dhiab (ORCID: https://orcid.org/0009-0007-4456-638X)
- Hanen Bouaziz (ORCID: https://orcid.org/0000-0001-5885-1252)
- Souhir Guidara
- Maroua Boujemaa (ORCID: https://orcid.org/0000-0001-7409-9240)
- Salma Kamoun (ORCID: https://orcid.org/0000-0003-0175-6136)
- Najet Mahjoub
- Mohamed Samir Boubaker
- Aïda Ayadi
Institutions
- Mohammed V University (MA)
- University of Sfax (TN)
- Institut Salah-Azaïz (TN)
- Hopital Universitaire Hedi Chaker (TN)
- Institut Pasteur de Tunis (TN)
- Institut Pasteur du Maroc (MA)
- Centre of Biotechnology of Sfax (TN)
- Abderrahmane Mami Hospital (TN)
- Tunis El Manar University (TN)
- University of Gabès (TN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12967-025-07027-8
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00