The multiple hit model of infantile and epileptic spasms: The 2025 update
Infantile and epileptic spasms syndrome (IESS) manifests with epileptic spasms and negatively affects the infants' development due to cognitive and behavioral problems. We have optimized the multiple-hit rat model of IESS to screen for new therapies and present here an overview of the model, which models drug-resistant IESS due to structural etiology. We also present new data on the acute effects of five drugs on spasms and a comparative assessment of all the treatments tested in this model for effects and tolerability on spasms, developmental deficits, adult epilepsy, and tolerability.
Authors
- Oleksii Shandra (ORCID: https://orcid.org/0000-0003-4447-3312)
- Anna‐Maria Katsarou (ORCID: https://orcid.org/0000-0003-0133-4582)
- Aristea S. Galanopoulou (ORCID: https://orcid.org/0000-0002-0472-2903)
- Wenzhu Mowrey (ORCID: https://orcid.org/0000-0002-7407-7014)
- Solomon L. Moshé (ORCID: https://orcid.org/0000-0001-9427-9476)
- Wei Liu (ORCID: https://orcid.org/0000-0003-4199-5406)
- Qianyun Li (ORCID: https://orcid.org/0000-0002-2014-3995)
Institutions
- Albert Einstein College of Medicine (US)
- Florida International University (US)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1002/epi4.70158
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- U.S. Department of Defense
- Citizens United for Research in Epilepsy
- National Institute of Neurological Disorders and Stroke