Protein translation dysregulation and immune cell evasion mediated by IFN and immunoproteasome downregulation define metastatic clones in HPV-related cancer of the oropharynx
This research elucidates multiple mechanisms driving the expansion of cancer clones in HPV-positive oropharyngeal cancer. By detailing the roles of translational adaptation, immunoproteasome dysfunction, suppression of the interferon immune response and cap-independent protein translation, we provide insights into how these processes contribute to immune evasion and tumour survival.
Authors
- Richard Gallagher (ORCID: https://orcid.org/0000-0002-3174-9618)
- Patricia Keith
- Walter Muskovic (ORCID: https://orcid.org/0000-0001-7529-1795)
- Peter Floros (ORCID: https://orcid.org/0000-0001-9522-0812)
- Rachael A. McCloy (ORCID: https://orcid.org/0000-0001-7791-4044)
- Brett Leavers
- Venessa Chin (ORCID: https://orcid.org/0000-0002-4630-4451)
- Himanshi Arora
- Dominik C. Kaczorowski (ORCID: https://orcid.org/0000-0002-9205-1934)
- José Alquicira-Hernández (ORCID: https://orcid.org/0000-0002-9049-7780)
- Joseph E. Powell (ORCID: https://orcid.org/0000-0002-5070-4124)
- Anne Senabouth (ORCID: https://orcid.org/0000-0002-8798-9821)
- Drew Neavin (ORCID: https://orcid.org/0000-0002-1783-6491)
- K. Sudhakar
- Julia Crawford
- Eleanor Spenceley
Institutions
- Garvan Institute of Medical Research (AU)
- UNSW Sydney (AU)
- The Kinghorn Cancer Centre (AU)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12916-025-04392-5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00