Targeting KRAS Inhibitor–Resistant Pancreatic Cancer with an MUC1-C Antibody–Drug Conjugate

These findings demonstrate that M1C confers resistance of PDAC to KRAS G12D inhibition and identify M1C as a potential target for ADC treatment of patients with PDAC who are refractory to KRAS inhibitors.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-10-14
DOI
https://doi.org/10.1158/1078-0432.ccr-25-2333
Citations
2
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
2.09
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article

Targeting KRAS Inhibitor–Resistant Pancreatic Cancer with an MUC1-C Antibody–Drug Conjugate

Yuko Kitagawa, Mai Onishi, Minoru Kitago, Mark D. Long et al.
2 citations
Clinical Cancer Research
Pancreatic and Hepatic Oncology Research
2.09
article

Targeting KRAS Inhibitor–Resistant Pancreatic Cancer with an MUC1-C Antibody–Drug Conjugate

Yuko Kitagawa, Mai Onishi, Minoru Kitago, Mark D. Long, Tomoki Motegi, Hirofumi Kawakubo, Atrayee Bhattacharya, Keisuke Shigeta, John Muschler, Zhou Luan, Akihisa Ueno, Donald Küfe, Shinkichi Takamori, Hiroki Ozawa, Justine J. Jacobi, Joseph Douglas Mancias, Andrew J. Aguirre, Rosalie C. Sears, Dove Keith, Kazumasa Fukuda, Keiko Takahashi
article en
2 citations

Abstract

These findings demonstrate that M1C confers resistance of PDAC to KRAS G12D inhibition and identify M1C as a potential target for ADC treatment of patients with PDAC who are refractory to KRAS inhibitors.

Clinical Cancer ResearchVol. 31(24)
Broad Institute (US), Roswell Park Comprehensive Cancer Center (US), Harvard University (US), Oregon Health & Science University (US), Keio University (JP), Keio University Hospital (JP), Shandong Provincial Hospital (CN), Dana-Farber Cancer Institute (US), Tokyo University of Agriculture and Technology (JP)
Openalex Percentile: Top 10%
Pancreatic and Hepatic Oncology Research
2.09
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