Targeting KRAS Inhibitor–Resistant Pancreatic Cancer with an MUC1-C Antibody–Drug Conjugate
These findings demonstrate that M1C confers resistance of PDAC to KRAS G12D inhibition and identify M1C as a potential target for ADC treatment of patients with PDAC who are refractory to KRAS inhibitors.
Authors
- Yuko Kitagawa (ORCID: https://orcid.org/0000-0001-6469-2155)
- Mai Onishi (ORCID: https://orcid.org/0000-0002-6733-0253)
- Minoru Kitago (ORCID: https://orcid.org/0000-0002-4909-1199)
- Mark D. Long (ORCID: https://orcid.org/0000-0003-1120-8176)
- Tomoki Motegi (ORCID: https://orcid.org/0000-0002-6811-0973)
- Hirofumi Kawakubo (ORCID: https://orcid.org/0000-0002-4929-5482)
- Atrayee Bhattacharya (ORCID: https://orcid.org/0000-0002-3322-6175)
- Keisuke Shigeta (ORCID: https://orcid.org/0000-0002-9405-9446)
- John Muschler (ORCID: https://orcid.org/0000-0001-9916-5937)
- Zhou Luan (ORCID: https://orcid.org/0009-0008-0692-2862)
- Akihisa Ueno (ORCID: https://orcid.org/0000-0001-9428-4128)
- Donald Küfe (ORCID: https://orcid.org/0000-0001-5743-8888)
- Shinkichi Takamori (ORCID: https://orcid.org/0000-0001-8175-6798)
- Hiroki Ozawa (ORCID: https://orcid.org/0000-0002-3771-7940)
- Justine J. Jacobi (ORCID: https://orcid.org/0000-0002-9109-3294)
- Joseph Douglas Mancias (ORCID: https://orcid.org/0000-0002-0692-3717)
- Andrew J. Aguirre (ORCID: https://orcid.org/0000-0002-0701-6203)
- Rosalie C. Sears (ORCID: https://orcid.org/0000-0003-1558-2413)
- Dove Keith (ORCID: https://orcid.org/0000-0001-6104-3264)
- Kazumasa Fukuda (ORCID: https://orcid.org/0000-0002-9917-4611)
- Keiko Takahashi (ORCID: https://orcid.org/0009-0000-3348-3860)
Institutions
- Broad Institute (US)
- Roswell Park Comprehensive Cancer Center (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- Keio University (JP)
- Keio University Hospital (JP)
- Shandong Provincial Hospital (CN)
- Dana-Farber Cancer Institute (US)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2333
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09