Neuroprotective Potential of C. pluricaulis in Stress Caused by Chronic Lower Back Pain

Introduction: Chronic Lower Back Pain (CLBP) is a common condition associated with psychological stress, which can exacerbate neuroinflammation and contribute to neurodegenerative changes. The herb Convolvulus pluricaulis (C. pluricaulis), or Śaṅkhapuṣpī, is known in Ayurvedic medicine for its cognitive-enhancing and neuroprotective properties. This review investigates the potential of C. pluricaulis to alleviate neurobiological disturbances linked to stress from CLBP. Materials and Methods: A review of literature from databases such as PubMed and Scopus was conducted to examine the phytochemical composition, biological effects, and experimental evidence regarding the neuroprotective role of C. pluricaulis. Studies focusing on oxidative stress, cytokine modulation, HPA axis regulation, and neurotrophic factor promotion were included. Results: C. pluricaulis contains compounds such as flavonoids, alkaloids, and terpenoids, which exhibit antioxidant, anti-inflammatory, and neuroprotective properties. Preclinical studies show it reduces oxidative stress and cytokine levels while modulating the HPA axis. Additionally, it enhances brain-derived neurotrophic factor (BDNF) levels, supporting neuronal survival and plasticity. Discussion: The herb’s effects on oxidative stress, inflammation, and neuroendocrine balance suggest its potential in treating neurodegeneration caused by chronic pain. While clinical studies are limited, preclinical data indicate that C. pluricaulis may serve as an adjunct therapy for managing stress-induced neurobiological changes in CLBP. Conclusion: C. pluricaulis shows promise in mitigating the neurological effects of stress related to CLBP; however, further clinical studies are needed to confirm its efficacy and safety. Keywords: Ayurveda, Musculoskeletal, Oxidative stress, Phytotherapy, Śaṅkhapuṣpī.