Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGFβ Axis
This study uncovers a surprising role for GCs in triggering CD8+ T cell-dependent tumor control through downregulation of GARP and thus TGFβ signaling. Analysis of samples from patients with melanoma suggested that GARP expression may serve as both a biomarker of poor antitumor immunity and a therapeutic target to improve the response to immunotherapy. See related commentary by Roest et al., p. 198.
Authors
- Pamela Dunn
- Matthew Roberts (ORCID: https://orcid.org/0000-0003-0737-266X)
- Eduardo Bonavita (ORCID: https://orcid.org/0000-0003-2335-5827)
- Agrin Moeini (ORCID: https://orcid.org/0000-0002-3323-7202)
- Alison L. Pidoux (ORCID: https://orcid.org/0009-0009-1928-6655)
- Massimo Russo (ORCID: https://orcid.org/0000-0002-4158-0377)
- Victoria Fife (ORCID: https://orcid.org/0000-0003-0052-5731)
- Kimberley Hockenhull (ORCID: https://orcid.org/0000-0003-0482-785X)
- Jérémie Nsengimana (ORCID: https://orcid.org/0000-0002-3603-4208)
- Theophile Bigirumurame (ORCID: https://orcid.org/0000-0003-2387-4918)
- Santiago Zelenay (ORCID: https://orcid.org/0000-0002-6865-3978)
- Caroline Dive (ORCID: https://orcid.org/0000-0002-1726-8850)
- Maria A. Koufaki (ORCID: https://orcid.org/0000-0002-5058-0176)
- Charlotte R. Bell (ORCID: https://orcid.org/0000-0001-8653-2291)
- Charles H. Earnshaw (ORCID: https://orcid.org/0000-0002-7926-8506)
- Alexander R. Baker (ORCID: https://orcid.org/0000-0002-3198-6779)
- Robert M. Sellers (ORCID: https://orcid.org/0000-0002-8193-9356)
- Christopher E.M. Griffiths (ORCID: https://orcid.org/0000-0001-5371-4427)
- Laëtitia Nebot-Bral (ORCID: https://orcid.org/0000-0001-8915-7052)
- Shih‐Chieh Chiang
- Julia Newton‐Bishop (ORCID: https://orcid.org/0000-0001-9147-6802)
- Erin Richardson (ORCID: https://orcid.org/0009-0003-8631-8254)
- Robert B. Reeves
- Suchitra Sahoo
Institutions
- Manchester Academic Health Science Centre (GB)
- St James's University Hospital (GB)
- Newcastle upon Tyne Hospital (GB)
- Cancer Research UK Manchester Institute (GB)
- NIHR Newcastle Biomedical Research Centre (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- Centre for Inflammation Research (GB)
- King's College Hospital (GB)
- National Computing Centre (United Kingdom) (GB)
- NIHR Manchester Biomedical Research Centre (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1224
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80