Clinical and genetic analysis of MOCOS gene-related hypouricemia
Sustained low serum uric acid levels may indicate monogenic uric acid metabolism disorders, and these patients should undergo genetic testing. In patients diagnosed with xanthinuria type II caused by <i>MOCOS</i> gene variants, the use of purine drugs should be prohibited to avoid serious adverse events. Given the severe defects in the <i>MOCOS</i> gene-deficient mouse model, additional research is needed to clarify the clinical profile of Xanthinuria type II and the other roles of MOCOS in metabolic pathways.
Authors
- Xiao Wei (ORCID: https://orcid.org/0000-0002-4092-3059)
- Xinyu Hu (ORCID: https://orcid.org/0009-0003-3047-1735)
- Huifang Peng (ORCID: https://orcid.org/0000-0003-2738-2080)
- Hongwei� Jiang (ORCID: https://orcid.org/0000-0003-3807-7989)
- Jinpeng Tang
- Yingyu Zhang
- Qing Ma (ORCID: https://orcid.org/0000-0002-0673-5222)
- Ping Tu
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Third Hospital of Nanchang (CN)
- Second Hospital of Nanchang (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fgene.2025.1636032
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00