Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells
Our epitranscriptomic analysis of A-to-I RNA editing underscores a multifaceted role for ADAR1-dependent editing in preserving genome integrity through post-transcriptional regulation of DNA repair genes, laying the groundwork for future studies into RNA-based mechanisms of genome maintenance.
Authors
- S. W. Song (ORCID: https://orcid.org/0009-0007-7085-8968)
- Zachary V. Johnson (ORCID: https://orcid.org/0000-0002-0101-6309)
- Akira Sassa (ORCID: https://orcid.org/0000-0003-2454-0223)
- Noriyuki Konishi (ORCID: https://orcid.org/0000-0002-1338-8759)
- Yu-Hsien Hwang Fu (ORCID: https://orcid.org/0000-0002-2861-4843)
- Yu-Qian Song
- Kiyoe Ura (ORCID: https://orcid.org/0000-0002-2424-2448)
- A Yoshida
- Hotaru Takaine
Institutions
- Chiba University (JP)
- Electronic BioSciences (United States) (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fgene.2025.1663827
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Japan Society for the Promotion of Science