Investigating the Application of Stem Cell Therapy for Regenerating Dentin in Patients with Traumatic Dental Injuries: A Database Research
Background: Traumatic dental injuries (TDIs) often compromise the dentin-pulp complex, necessitating innovative therapeutic approaches. Stem cell therapy has emerged as a promising solution for regenerative endodontics. Objective: This research investigates the application of stem cell therapy in regenerating dentin for patients with TDIs by using a retrospective analysis of clinical outcomes. Methods: A retrospective data analysis was performed on 120 cases involving TDIs treated with stem cell-based interventions. Key parameters included patient demographics, clinical outcomes, and histological findings. Statistical significance was assessed using a P value of <0.05. Results: Significant improvement in dentin regeneration was observed in 85% of cases treated with stem cell therapy. Histological findings confirmed the formation of tubular dentin in 75% of cases. Younger patients exhibited superior outcomes compared to older cohorts. Conclusion: Stem cell therapy demonstrates significant potential for regenerating dentin in TDIs. Future studies should explore long-term outcomes and optimization of protocols.
Authors
- Rahul Tiwari (ORCID: https://orcid.org/0000-0003-4156-776X)
- Shilpa S. Shetty (ORCID: https://orcid.org/0000-0002-5832-5567)
- Khushboo Changani
- Anil Managutti (ORCID: https://orcid.org/0000-0003-4958-8346)
- Pratik K. Agrawal (ORCID: https://orcid.org/0000-0003-1578-308X)
- Anjum Patan
Institutions
- Manubhai Patel Dental College and Hospital (IN)
- Mamata Medical College (IN)
- Tatyasaheb Kore Dental College and Research Centre (IN)
- Sankalchand Patel University (IN)
- KIIT University (IN)
Publication Details
- Journal
- Journal of Pharmacy And Bioallied Sciences
- Published
- 2025-10-13
- DOI
- https://doi.org/10.4103/jpbs.jpbs_552_25
- Primary Topic
- Dental Trauma and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00