Investigating the Application of Stem Cell Therapy for Regenerating Dentin in Patients with Traumatic Dental Injuries: A Database Research

Background: Traumatic dental injuries (TDIs) often compromise the dentin-pulp complex, necessitating innovative therapeutic approaches. Stem cell therapy has emerged as a promising solution for regenerative endodontics. Objective: This research investigates the application of stem cell therapy in regenerating dentin for patients with TDIs by using a retrospective analysis of clinical outcomes. Methods: A retrospective data analysis was performed on 120 cases involving TDIs treated with stem cell-based interventions. Key parameters included patient demographics, clinical outcomes, and histological findings. Statistical significance was assessed using a P value of <0.05. Results: Significant improvement in dentin regeneration was observed in 85% of cases treated with stem cell therapy. Histological findings confirmed the formation of tubular dentin in 75% of cases. Younger patients exhibited superior outcomes compared to older cohorts. Conclusion: Stem cell therapy demonstrates significant potential for regenerating dentin in TDIs. Future studies should explore long-term outcomes and optimization of protocols.

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Publication Details

Journal
Journal of Pharmacy And Bioallied Sciences
Published
2025-10-13
DOI
https://doi.org/10.4103/jpbs.jpbs_552_25
Primary Topic
Dental Trauma and Treatments
Type
article
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article

Investigating the Application of Stem Cell Therapy for Regenerating Dentin in Patients with Traumatic Dental Injuries: A Database Research

Rahul Tiwari, Shilpa S. Shetty, Khushboo Changani, Anil Managutti et al.
Journal of Pharmacy And Bioallied Sciences
Dental Trauma and Treatments
article

Investigating the Application of Stem Cell Therapy for Regenerating Dentin in Patients with Traumatic Dental Injuries: A Database Research

Rahul Tiwari, Shilpa S. Shetty, Khushboo Changani, Anil Managutti, Pratik K. Agrawal, Anjum Patan
article en

Abstract

Background: Traumatic dental injuries (TDIs) often compromise the dentin-pulp complex, necessitating innovative therapeutic approaches. Stem cell therapy has emerged as a promising solution for regenerative endodontics. Objective: This research investigates the application of stem cell therapy in regenerating dentin for patients with TDIs by using a retrospective analysis of clinical outcomes. Methods: A retrospective data analysis was performed on 120 cases involving TDIs treated with stem cell-based interventions. Key parameters included patient demographics, clinical outcomes, and histological findings. Statistical significance was assessed using a P value of <0.05. Results: Significant improvement in dentin regeneration was observed in 85% of cases treated with stem cell therapy. Histological findings confirmed the formation of tubular dentin in 75% of cases. Younger patients exhibited superior outcomes compared to older cohorts. Conclusion: Stem cell therapy demonstrates significant potential for regenerating dentin in TDIs. Future studies should explore long-term outcomes and optimization of protocols.

Journal of Pharmacy And Bioallied SciencesVol. 18(2)
Manubhai Patel Dental College and Hospital (IN), Mamata Medical College (IN), Tatyasaheb Kore Dental College and Research Centre (IN), Sankalchand Patel University (IN), KIIT University (IN)
Openalex Percentile: Top 56%
Dental Trauma and Treatments
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