International Survey on Evidence for Index Lymph Node Surgery After Neoadjuvant Systemic Therapy for Stage III Melanoma
The current evidence supports the use of neoadjuvant immunotherapy as the standard of care for stage III melanoma. However, widespread clinical adoption of ILN-guided surgical de-escalation remains limited. A multicenter phase 3 trial (MSLT-3), launching in 2025, is expected to provide important data to guide future practice.
Authors
- David Gyorki (ORCID: https://orcid.org/0000-0002-3165-4694)
- Jonathan S. Zager (ORCID: https://orcid.org/0000-0002-6886-4468)
- Paolo A. Ascierto (ORCID: https://orcid.org/0000-0002-8322-475X)
- Jennifer Ann Wargo (ORCID: https://orcid.org/0000-0003-3438-7576)
- Merrick I. Ross (ORCID: https://orcid.org/0000-0002-7787-0421)
- Hussein Tawbi
- Elan Novis (ORCID: https://orcid.org/0009-0003-0734-8309)
- Tina J. Hieken (ORCID: https://orcid.org/0000-0002-4277-8692)
- Georgina Venetia Long (ORCID: https://orcid.org/0000-0001-8894-3545)
- Mervi Rautalin (ORCID: https://orcid.org/0000-0002-9427-7689)
- Piotr Rutkowski (ORCID: https://orcid.org/0000-0002-8920-5429)
- Alexander C. J. van Akkooi (ORCID: https://orcid.org/0000-0002-3262-6935)
- Dirk J. Grünhagen (ORCID: https://orcid.org/0000-0001-8293-6002)
- Mark B. Faries (ORCID: https://orcid.org/0000-0003-1752-7282)
- Christian U. Blank (ORCID: https://orcid.org/0000-0002-7945-5846)
- Andrew Hayes (ORCID: https://orcid.org/0000-0002-9832-4219)
- Alexander M Menzies
- Anke Kuijpers
- Rodabe Navroze Amaria
- Joshua M.V. Mammen
- Michael T. Tetzlaff
Institutions
- The University of Sydney (AU)
- Mayo Clinic (US)
- University of Helsinki (FI)
- The University of Texas MD Anderson Cancer Center (US)
- University of California, San Francisco (US)
- University of South Florida (US)
- Royal Prince Alfred Hospital (AU)
- Royal North Shore Hospital (AU)
- Helsinki University Hospital (FI)
- Peter MacCallum Cancer Centre (AU)
- Erasmus MC (NL)
- The Netherlands Cancer Institute (NL)
- Moffitt Cancer Center (US)
- Angeles Clinic and Research Institute (US)
- Melanoma Institute Australia (AU)
- Royal Marsden Hospital (GB)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- University of Nebraska Medical Center (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1245/s10434-025-18475-3
- Citations
- 2
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.09