β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator
Extracellular β-NAD relaxes airway smooth muscle via a noncanonical, cAMP-linked pathway that is independent of classical Gi- and Gs-coupled receptor signaling. This pathway is enhanced by PDE4 inhibition and likely involves localized cAMP pools generated by transmembrane adenylyl cyclases. These findings identify β-NAD as a potential modulator of airway tone and support further exploration of its physiological and therapeutic relevance.
Authors
- Anna Zakrzewicz (ORCID: https://orcid.org/0000-0001-9004-3706)
- Andreas Hecker (ORCID: https://orcid.org/0000-0002-7704-7494)
- Walter Klepetko (ORCID: https://orcid.org/0000-0003-4174-6071)
- Arianna Sanna (ORCID: https://orcid.org/0009-0002-6282-6003)
- Silke Wiegand
- Innokentij Jurastow (ORCID: https://orcid.org/0000-0002-5946-3363)
- Muhammad Rafiq (ORCID: https://orcid.org/0000-0002-0068-038X)
- Daniel von der Beck (ORCID: https://orcid.org/0000-0003-1946-9303)
- Gabriela Krasteva‐Christ (ORCID: https://orcid.org/0000-0002-0113-521X)
- Maryam Keshavarz (ORCID: https://orcid.org/0000-0002-8917-2508)
- Andreas Güenther (ORCID: https://orcid.org/0000-0002-2187-0975)
- Moritz Bünemann
- Sandra Engel
Institutions
- Philipps University of Marburg (DE)
- Justus-Liebig-Universität Gießen (DE)
- Vienna General Hospital (AT)
- Institut für Sozialforschung und Sozialwirtschaft (DE)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- Cardio-Pulmonary Institute (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Saarland University (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1371/journal.pone.0334491
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00