Biotinidase as a novel biomarker for pain assessment in dairy cattle
These findings provide compelling new evidence that plasma biotinidase responds robustly to diverse pain stimuli in nonhuman mammals. Further studies should investigate its diagnostic performance individually, and alongside other biochemical, physiological, and behavioral indicators, to enhance pain assessment accuracy and of noninvasive pain detection protocols for farm animals.
Authors
- Einav Shor-Shimoni
- Maya Ross (ORCID: https://orcid.org/0000-0001-6525-7032)
- Hen Honig (ORCID: https://orcid.org/0000-0003-3723-7274)
- Aviv Asher (ORCID: https://orcid.org/0000-0002-1480-438X)
- Yael Salzer (ORCID: https://orcid.org/0000-0001-9771-0452)
- Shmuel Friedman
- Yael Shilo‐Benjamini (ORCID: https://orcid.org/0000-0002-5468-1070)
- Ariel Shabtay
- Noa Yitzhak
Institutions
- Hebrew University of Jerusalem (IL)
- Agricultural Research Organization (IL)
- Israel Dairy Board (Israel) (IL)
- Migal - Galilee Technology Center (IL)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1097/pr9.0000000000001338
- Primary Topic
- Biotin and Related Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00