Associations between systemic inflammation response index and abdominal aortic calcification: a cross-sectional study

The relationship between Systemic Inflammation Response Index (SIRI) and abdominal aortic calcification (AAC) remains unexplored. Data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) cohort were analyzed. AAC and severe AAC (SAAC) were quantified using the Kauppila scoring system. Multivariate linear and logistic regression were applied to examine the correlation between SIRI and AAC scores, as well as SIRI and SAAC. The predictive value of SIRI and the Systemic Immune Inflammatory Index (SII) for SAAC was compared using ROC curves and Delong test. A nomogram model for SAAC prediction was also constructed. A total of 3,047 participants were included. Results showed a significant positive association between SIRI and higher AAC scores, with scores increasing progressively across higher SIRI quartiles. A similar positive trend was observed between SIRI and SAAC prevalence. Subgroup analysis revealed that the relationship between SIRI and AAC scores was stronger in the elderly. The SAAC predictive model, incorporating SIRI and other factors, achieved an area under the curve (AUC) of 0.86 in the training set and 0.81 in the validation set. This study suggests that higher SIRI is positively associated with both AAC and SAAC, with superior predictive value for SAAC compared to SII.