Tamoxifen‐Induced Liver Injury in Patients With Breast Cancer: Frequency, Risk Factors and Clinical Course
Tamoxifen-induced liver injury was observed in 15.6% of the patients. Metabolic factors, such as high BMI, diabetes, dyslipidemia and pre-existing liver steatosis, were considered potential predictors of CTCAE grade ≥ 2 liver injury. Collaboration with gastroenterologists should be encouraged in patients with grade ≥ 2 liver injuries, where spontaneous remission is uncommon.
Authors
- Mitsunori Nishikawa (ORCID: https://orcid.org/0000-0002-6325-808X)
- Takahisa Kayahara
- Shiro Imai
- Masayuki Ueno (ORCID: https://orcid.org/0000-0002-2497-9327)
- Ayako Ueno (ORCID: https://orcid.org/0000-0003-4624-0731)
- Machiko Karai
- Kazushige Yamaguchi
- Hiroyuki Takabatake
- Youichi Morimoto
Institutions
- Kyoto University (JP)
- Kurashiki Central Hospital (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1111/hepr.70059
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56