Assessing the Genetic Integrity of Embryos Carrying X/Y-Autosome-Balanced Translocations through SNP-Based PGT-SR
The impact of chromosomal translocation on reproduction is contingent upon whether the breakpoint location influences critical functional regions. SNP-based PGT-SR can accurately determine the genetic status of embryos exhibiting balanced X/Y-autosomal translocations by systematically evaluating the integrity of the embryo's genetic material. This approach enhances detection accuracy and mitigates the risk of transmitting the translocation to subsequent generations.
Authors
- Xianglian Tang (ORCID: https://orcid.org/0000-0002-4101-4391)
- Caizhu Wang (ORCID: https://orcid.org/0000-0002-7649-6394)
- Wei Yuan (ORCID: https://orcid.org/0000-0001-5117-3639)
- Jinhui Shu (ORCID: https://orcid.org/0000-0002-0052-4424)
- Peng Huang (ORCID: https://orcid.org/0000-0002-8367-8196)
- Xin Zhao (ORCID: https://orcid.org/0000-0003-3482-4481)
- Chaofan Zhou (ORCID: https://orcid.org/0000-0002-2095-4034)
- Yueyun Lan
- Wei Li (ORCID: https://orcid.org/0000-0002-1074-9213)
- Zhan Li (ORCID: https://orcid.org/0000-0001-9624-9545)
- Sheng He (ORCID: https://orcid.org/0000-0003-2918-1549)
- Jiasun Su (ORCID: https://orcid.org/0000-0002-1944-8441)
- Hong Zhou
- Qingming Qiu
- Minpan Huang
- Jingsi Luo
Institutions
- Guangxi Maternal and Child Health Hospital (CN)
- Guangxi Center for Disease Prevention and Control (CN)
Publication Details
- Journal
- Cytogenetic and Genome Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1159/000548936
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00