Carcinomas exhibiting epithelial–mesenchymal transition manifest an M2 macrophage-enriched tumor immune microenvironment
Given the immunosuppressive role of M2 macrophages, our findings suggest that an EMT-driven, M2 macrophage-enriched TME-a consistent phenomenon across organs-can contribute to immune suppression. This underscores the therapeutic potential of macrophage-targeting strategies and immune checkpoint inhibition in treating aggressive carcinosarcomas characterized by EMT-mediated, M2 macrophage-rich TMEs.
Authors
- Yen‐Shen Lu (ORCID: https://orcid.org/0000-0001-7461-1291)
- Ruby Yun‐Ju Huang (ORCID: https://orcid.org/0000-0001-6376-3185)
- Ling-Chun Yeh
- Huang‐Chun Lien (ORCID: https://orcid.org/0000-0003-1472-1231)
- Yu-Chia Li (ORCID: https://orcid.org/0000-0001-6989-2375)
- I‐Chun Chen (ORCID: https://orcid.org/0000-0001-9342-7596)
- Tom Wei‐Wu Chen (ORCID: https://orcid.org/0000-0003-4112-4029)
- Ko-Chen Chen
- Li-Ping Hsiao
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13058-025-02119-1
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council