Therapeutic evaluation of iPSC-derived CD146+ mesenchymal stem cells in ulcerative colitis: biological properties and potential mechanisms
CD146+iMSCs exhibited advantages in proliferative and differentiation capabilities. They could ameliorate UC by suppressing IL-17 expression, downregulating HUB genes, and modulating macrophage polarization through the cGAS-STING axis.
Authors
- Yuxin Lu (ORCID: https://orcid.org/0000-0001-6587-2967)
- Fengjun Xiao (ORCID: https://orcid.org/0000-0003-4743-6146)
- Jun Fan (ORCID: https://orcid.org/0000-0002-1433-7283)
- Mingru Zong
- Tian Lv (ORCID: https://orcid.org/0000-0002-9580-9990)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-1998-0611)
- Yiming Wang (ORCID: https://orcid.org/0000-0001-7330-2235)
- Lei Shen (ORCID: https://orcid.org/0000-0002-3509-484X)
- Li Du (ORCID: https://orcid.org/0009-0002-0334-192X)
- Xiaochen Cheng
Institutions
- University of Electronic Science and Technology of China (CN)
- Jilin University (CN)
- Chinese PLA General Hospital (CN)
- Quzhou City People's Hospital (CN)
- Institute of Experimental Physics of the Slovak Academy of Sciences (SK)
- Beijing Research Institute of Mechanical and Electrical Technology (CN)
- Quzhou University (CN)
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
- Changchun University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13287-025-04695-7
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00