ROS-responsive 3D biological scaffold delivers hypoxia-primed extracellular vesicles for targeted modulation of neuroinflammation in intracerebral hemorrhage
The ROS-responsive 3D biological scaffold -mediated delivery of Hypo-Exos modulates neuroinflammation through ubiquitination pathways, stabilizes the early-phase ICH microenvironment, and improves functional recovery. This platform represents a promising therapeutic strategy for ICH, offering dual advantages as a drug delivery system and a regenerative therapy.
Authors
- Chengrui Nan
- Aobo Zhang (ORCID: https://orcid.org/0000-0003-0568-8601)
- Dan Qiao
- Zhanzhan Zhang (ORCID: https://orcid.org/0009-0004-0659-0125)
- Ziyang Jia (ORCID: https://orcid.org/0000-0001-8923-3385)
- Dongdong Yan
- Yunpeng Shi
- Liqiang Liu (ORCID: https://orcid.org/0000-0001-5325-9399)
Institutions
- Hebei Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13287-025-04691-x
- Citations
- 1
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39