Secretome from human placenta-derived mesenchymal stem cells repairs mechanically induced meniscus injury in mice by activating the proliferation and suppressing the apoptosis of endogenous meniscus progenitor cells
To the best of our knowledge, this is the first study demonstrating that the human pcMSC secretome promotes meniscus regeneration through activating endogenous meniscus progenitor cells both in vivo and in vitro. Our findings suggest that these regenerative effects are mediated by growth factors and exosomal miRNAs in the pcMSC secretome. The potential exosomal miRNAs effectively modulated ECM formation, anti-apoptosis, anti-inflammation, and anti-cartilage matrix degradation to mitigate MPCs injury. Overall, this study provides valuable insights into potential stem cell-derived secretome cell-free therapies for patients with exercise-induced meniscus injuries.
Authors
- Gee‐Way Lin (ORCID: https://orcid.org/0000-0001-7242-1558)
- Yen‐Hua Huang (ORCID: https://orcid.org/0000-0001-6020-9998)
- Thai‐Yen Ling (ORCID: https://orcid.org/0000-0002-3992-883X)
- Weiheng Chen
- Wei-Yu Lai (ORCID: https://orcid.org/0000-0003-2657-0346)
- Mai-Huong Thi Ngo (ORCID: https://orcid.org/0009-0009-4026-8099)
- Cheng-Xiang Kao (ORCID: https://orcid.org/0000-0002-5248-7928)
- Yung‐Che Kuo (ORCID: https://orcid.org/0000-0002-9425-7389)
- Kang-Yun Fan
- Duy‐Cuong Le
- Jui-Chien Hsing
Institutions
- University of Southern California (US)
- National Taiwan University (TW)
- Taipei Medical University Hospital (TW)
- Vinmec Times City International Hospital (VN)
- Taipei Medical University (TW)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13287-025-04688-6
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academia Sinica
- Taipei Medical University
- National Science and Technology Council
- Genomics Research Center, Academia Sinica