Network pharmacology and experimental study on the inhibition of glycolysis by amentoflavone in pancreatic cancer
Our study elucidates that amentoflavone inhibits pancreatic cancer development by regulating the glycolysis process through the suppression of the PI3K/AKT/mTOR pathway, thereby providing novel targets and therapeutic strategies for the treatment of pancreatic cancer.
Authors
- Tanveer Ali (ORCID: https://orcid.org/0000-0002-6377-0673)
- Xu He (ORCID: https://orcid.org/0000-0002-4044-3186)
- Kaiyue Ding
- Lin Zhang (ORCID: https://orcid.org/0000-0003-0424-9965)
- Peng Chen (ORCID: https://orcid.org/0000-0002-7553-3640)
- Zhihao Zhao (ORCID: https://orcid.org/0009-0002-3092-7985)
- Junnan Ma
- Xingchen Wu (ORCID: https://orcid.org/0009-0005-8194-4939)
- HyokChol Choe
Institutions
- Dalian Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1007/s12672-025-03697-4
- Citations
- 2
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 1.61