Single-cell RNA-seq combined with bulk RNA-seq analysis identifies necroptosis-related genes as therapeutic targets for periodontitis
Our study identified six hub genes (CSF3R, CSF2RB, BTG2, CXCR4, GPSM3, and SSR4) highly expressed in periodontitis tissues and positively correlated with necroptosis. These genes may serve as therapeutic targets for inflammatory diseases like periodontitis.
Authors
- Songlin Shi (ORCID: https://orcid.org/0000-0003-1213-0550)
- Qianju Wu (ORCID: https://orcid.org/0000-0002-9711-7058)
- Mingyan Xu (ORCID: https://orcid.org/0000-0002-0082-403X)
- Rui Huang (ORCID: https://orcid.org/0000-0002-1546-118X)
- Feixiang Zhu (ORCID: https://orcid.org/0000-0001-9579-0874)
- Xiaoling Deng (ORCID: https://orcid.org/0000-0001-9163-7194)
- Fan Liu (ORCID: https://orcid.org/0000-0002-9481-0797)
- Hongfa Yao
- Yixin Xiao
Institutions
- Xiamen University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12920-025-02241-1
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81