Association between antemortem plasma and structural MRI biomarkers and postmortem tau pathology in the Mayo Clinic Study of Aging
Our study demonstrates the greater sensitivity of regional MRI to tau pathology in comparison to plasma biomarkers. Future studies should explore newer MRI methods and additional plasma biomarkers more specific to tau pathology such as microtubule binding region for prediction of antemortem tau pathology.
Authors
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Terry M. Therneau (ORCID: https://orcid.org/0000-0003-1490-6711)
- Ekaterina I. Hofrenning (ORCID: https://orcid.org/0000-0003-2266-6746)
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Christina M. Moloney (ORCID: https://orcid.org/0000-0002-4258-2294)
- Aivi T. Nguyen (ORCID: https://orcid.org/0000-0003-1809-9451)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Darren M. Rothberg
- Robert Ross Reichard (ORCID: https://orcid.org/0000-0003-0842-2462)
- Angela J. Fought (ORCID: https://orcid.org/0000-0002-7486-8596)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Mingzhao Hu
Institutions
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13195-025-01852-1
- Citations
- 2
- Primary Topic
- Autopsy Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Mayo Clinic
- GHR Foundation
- National Institutes of Health
- National Institute on Aging