Glutaminase activity maintains NK cell cytotoxicity through metabolic regulation of effector function
Our findings highlight the importance of glutaminase activity in supporting NK cell respiratory metabolism and cytotoxic function, and the need for caution when combining glutaminase inhibitors with NK cell-based therapies.
Authors
- Farah Jahan (ORCID: https://orcid.org/0000-0001-9991-9575)
- Matti Korhonen (ORCID: https://orcid.org/0000-0002-1573-0458)
- Tereza Feglarová
- Jan Frič (ORCID: https://orcid.org/0000-0001-6642-797X)
- Jana Szabová
- Marek Jedlička
- Marcela Hortová Kohoutková (ORCID: https://orcid.org/0000-0003-1090-1665)
- Eva Mašínová
- Kateřina Kuželová (ORCID: https://orcid.org/0000-0002-9628-6255)
- Kateřina Kuglerová
- Veronika Švubová
- V. Graman
Institutions
- Charles University (CZ)
- Masaryk University (CZ)
- Finnish Red Cross (FI)
- Institute of Haematology and Blood Transfusion (CZ)
- International Clinical Research Center, St. Anne's University Hospital Brno (CZ)
- St. Anne's University Hospital Brno (CZ)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12950-025-00470-w
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80