Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS

Quantifying ECS by deconvolution supports a transcriptomics-driven approach towards the non-invasive evaluation of endothelial damage in respiratory outcomes. This is a first step towards elucidating mechanistic components linking endothelial damage to ARDS utilizing non-invasive, circulating transcriptomic data by leveraging a novel deconvolution approach.

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Publication Details

Journal
Critical Care
Published
2025-10-14
DOI
https://doi.org/10.1186/s13054-025-05596-0
Citations
1
Primary Topic
Respiratory Support and Mechanisms
Type
article
Field-Weighted Citation Impact
1.52

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article

Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS

Grace A. McComsey, David Elashoff, Walter L. Eckalbar, Nicolas C. Issa et al.
1 citations
Critical Care
Respiratory Support and Mechanisms
1.52
article

Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS

Grace A. McComsey, David Elashoff, Walter L. Eckalbar, Nicolas C. Issa, Lekshmi Santhosh, Joann Diray‐Arce, Luz Torres Altamirano, Jeremy P. Gygi, Bonny D. Alvarenga, Hanno Steen, Lauren A. Sinko, Charles Langelier, Greg K. Tharp, Lauren R. Sorce, William Ruff, Nataliya Melnyk, Harry Pickering, Priya Prasad, Janice E. Sullivan, Saurabh Asthana, Jeff Milush, Jarrod Mosier, Kerin Hurley, Keith Farrugia, R. Sharon Chinthrajah, Amer Bechnak, Leying Guan, Michael Adkisson, Maria C. Bermúdez‐González, Trina Hughes, Subhasis Mohanty, Alyssa Ward, George A. Yendewa, Jenny Brook, Tatyana Vaysman, Elsio A. Wunder, Elizabeth Beagle, Allyson Molzahn, Debra Powell, Kerry McEnaney, Jessica Ann Lasky-Su, Carolyn Leroux, Caroline Ciric, James A. Overton, Christina Montesano, Norman L. Jones, Hrishikesh S. Kulkarni, Lauren I. R. Ehrlich, Maimouna D. Murphy, Akiko Iwasaki, Jennifer A. Fulcher, David J. Erle, Nathan D. Grubaugh, Chris Bime, Grace Chong, Kayley Wong, Alejandra Jáuregui, Matteo Pellegrini, Lauren T. Hewitt, Anderson Fernandes Brito, Ebony Nelson, Albert Icksang Ko, Jessica Cauley, X. Wang, S. Wimalasena, Heidi L. Erickson, Ruth R. Montgomery, Mark G. Martens, Legna Betancourt, Annmarie Hoch, William B. Messer, Juan Manuel Carreño, Samuel Yang, Zhengchun Lu, Arthur Viodé, Michael S. D. Agus, Benoit Fatou, Arash Nemati Hayati, Charles S. Dela Cruz, Viviana Simon, Carolyn M. Hendrickson, Eran Mick, Zoë L. Lyski, Sanya Thomas, Matthew F. Krummel, Susan Pereira Ribeiro, Simon D. van Haren, Brandi Johnson, Carly E. Milliren, Neethi Pinto, Lily Eaker, Sara Furukawa, Clara E. Magyar, Alexander J. Beagle, Adeeb Rahman, Xhoi Mitre, Renee McLin, Albert C. Shaw, Scott J. Tebbutt, Alan Pinto, Natalie Z. Cvijanovich, Douglas A. Drevets, Michele A. Kutzler, Jessica E. Rothman, M. Catherine Muenker, George P. Tegos, Temima Yellin, Eliotte L. Hirshberg, Stephen R. Walsh, Arjun A. Rao, Jingjing Qi, Justin F. Rousseau, Kieffer Hellmeister, Patrick van Zalm, Nathan Mege, Shanshan Liu, Shelli Farhadian, Tanzia Shaheen, Ana C. Chang, Kari Christine Nadeau, Bethany Evans, Christopher J. L. Newth, Sadeed Rashid, Jacob Usher, Edward S. Lee, Kevin Mendez, Myke Federman, Vijay Srinivasan, Meenakshi Jha, Jordan P. Metcalf, Raphael Lota, Kyra Woloszczuk, Brent Simmons, Janelle N. Geltman, Shirley Viteri, Fei‐Man Hsu, Jose Humberto Licona, Kinga K. Smolen, Estefania Ramires‐Sanchez, Marcy Singleton, Yael Rosenberg‐Hasson, Jun Bai Park Chang, Sholeen Nett, Hui Xie, Casey P. Shannon, Brunilda Balliu, Matthew R. Bell, Michael D. Leipold, Michaël Desjardins, I. Michael Goonewardene, Manishkumar Patel, Scott F. Sieg, Slim Fourati, Rafick‐Pierre Sékaly, Charles B. Cairns, Jonathan Paul Singer, Nadine Rouphael, Neera Ahuja, Hiromitsu Asashima, Azlann Arnett, Felicity J. Coulter, Miti Saksena, Mitchell Cooney, Bjoern Peters, Peter E. 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Shulz, Henna Naz Din, Pam Schearer, Judie Sheidy, Zain Khalil
article en
1 citations

Abstract

Quantifying ECS by deconvolution supports a transcriptomics-driven approach towards the non-invasive evaluation of endothelial damage in respiratory outcomes. This is a first step towards elucidating mechanistic components linking endothelial damage to ARDS utilizing non-invasive, circulating transcriptomic data by leveraging a novel deconvolution approach.

Critical CareVol. 29(1)
Broad Institute (US), University of Southern California (US), Boston Children's Hospital (US), National Institutes of Health (US), La Jolla Institute for Immunology (US), Harvard University (US), University of Arizona (US), Emory University (US), University of California, Los Angeles (US), Oregon Health & Science University (US), University of California, San Francisco (US), University of Washington (US), University Hospitals of Cleveland (US), Yale University (US), University of Florida (US), Immunai (United States) (US), Baylor School (US), VA Greater Los Angeles Healthcare System (US), OU Health, University of Oklahoma Health Sciences Center (US), Case Western Reserve University (US), Drexel University (US), The University of Texas at Austin (US), Florida College (US), Stanford University (US), Icahn School of Medicine at Mount Sinai (US)
U.S. Department of Veterans Affairs, Emory University, University of Washington, Case Western Reserve University, Drexel University, National Institutes of Health, School of Medicine, Stanford University, University of California, Los Angeles, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles
Openalex Percentile: Top 14%
Respiratory Support and Mechanisms
1.52
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