Early-life exposure to tobacco smoke increase risk of frailty in adulthood: evidence from a large prospective cohort study
Early-life tobacco exposure could increase frailty risk and this association only partly explained by cumulative smoking exposure. Inflammatory marker and telomere length mediate this relationship. Our findings emphasize the importance of early-life preventive measures such as antenatal counseling and school-based interventions to reduce frailty risk in later life.
Authors
- Yimin Zhu (ORCID: https://orcid.org/0000-0001-8409-7636)
- Zhenghui Li (ORCID: https://orcid.org/0000-0002-3721-4243)
- Xuhui Zhang (ORCID: https://orcid.org/0000-0003-2391-7201)
- Zhaoping Wang (ORCID: https://orcid.org/0000-0003-2069-070X)
- Senhai Yu
Institutions
- Sir Run Run Shaw Hospital (CN)
- Hangzhou Center for Disease Control and Prevention (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- Community Health Center (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12967-025-07138-2
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China