The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia
In summary, we found that rs429358 (APOE ε4) may influence the survival time of patients with PD not only through its association with dementia but also independently.
Authors
- Qian Xu (ORCID: https://orcid.org/0000-0002-5223-9967)
- Li Lu (ORCID: https://orcid.org/0000-0003-2523-3372)
- Hongxu Pan (ORCID: https://orcid.org/0000-0003-4255-5904)
- Long Qin (ORCID: https://orcid.org/0000-0001-9995-7176)
- Yinghong Dai
- Jinchen Li (ORCID: https://orcid.org/0000-0001-5522-806X)
- Beisha Tang (ORCID: https://orcid.org/0000-0003-2120-1576)
- Li B (ORCID: https://orcid.org/0000-0002-4906-4457)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-8388-6139)
- Shiyu Zhang (ORCID: https://orcid.org/0000-0001-5181-5128)
- Guihu Zhao (ORCID: https://orcid.org/0000-0003-4033-1843)
- Yijing Wang (ORCID: https://orcid.org/0000-0001-7666-9323)
- Qiao Zhou (ORCID: https://orcid.org/0000-0001-5929-5438)
- Jian Qiu (ORCID: https://orcid.org/0000-0002-7049-200X)
- Yuanfeng Huang
Institutions
- Central South University (CN)
- Hunan University (CN)
- National Clinical Research (US)
- First Affiliated Hospital of University of South China (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12967-025-07169-9
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Central South University
- Xiangya Hospital, Central South University
- Fundamental Research Funds for the Central Universities