Quantitative dual-isotope preclinical SPECT/CT imaging and biodistribution of the mercury-197m/g theranostic pair with [197m/gHg]HgCl2 and a [197m/gHg]Hg-tetrathiol complex as a platform for radiopharmaceutical development
These results establish Tetrathiol as a promising scaffold for mercury-based theranostics, offering efficient radiolabeling and in vivo stability. The integration of high-resolution imaging and HgQuant-based quantification of each isomer establishes a comprehensive framework for advancing [<sup>197m/g</sup>Hg]Hg radiopharmaceutical development.
Authors
- Valery Radchenko (ORCID: https://orcid.org/0000-0002-4742-6565)
- Patrick R. W. J. Davey (ORCID: https://orcid.org/0000-0002-8774-0030)
- Caterina F. Ramogida (ORCID: https://orcid.org/0000-0003-4815-2647)
- Parmissa Randhawa (ORCID: https://orcid.org/0000-0002-7280-5524)
- Cristina Rodríguez‐Rodríguez (ORCID: https://orcid.org/0000-0002-3313-4422)
- Shaohuang Chen (ORCID: https://orcid.org/0000-0002-0112-7949)
- Helena Koniar (ORCID: https://orcid.org/0000-0003-0794-9115)
Institutions
- TRIUMF (CA)
- University of British Columbia (CA)
- Simon Fraser University (CA)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s41181-025-00391-2
- Citations
- 1
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- TRIUMF
- University of Toronto
- Alliance de recherche numérique du Canada
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada