Construction and validation of a lactylation-based gene signature for prognostic assessment and immune infiltration analysis in gastric adenocarcinoma
DHRS7 has the potential to shift from acting as a tumor suppressor to functioning as an oncogene in modified TMEs, despite its lower expression levels in STAD tissues relative to normal tissues. This transformation accounts for the association between high DHRS7 expression in the later stages of STAD and a negative prognosis.
Authors
- Shiwei Guo (ORCID: https://orcid.org/0000-0003-4154-2781)
- Shuping Wu
- Wenjun Xie (ORCID: https://orcid.org/0000-0001-8101-5519)
- Gaojian Zhuang
- Jialin Chen (ORCID: https://orcid.org/0000-0001-6294-876X)
- Yu Zeng (ORCID: https://orcid.org/0000-0003-4432-6443)
Institutions
- Fujian Medical University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Fujian Provincial Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12920-025-02244-y
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00