Effects of zacopride and multidimensional impacts of cross-kingdom symbiosis: gut microbiota modulates coronary microvascular dysfunction via the chlorophyll/heme-tryptophan metabolic axis
This study provides the first evidence that the gut microbiota modulates the pathogenesis of CMD through the "chlorophyll/heme-tryptophan metabolic axis." Furthermore, we demonstrate that Zacopride exerts therapeutic effects by remodeling microbiota-host interactions and regulating this metabolic axis, revealing a novel mechanistic link between microbial metabolism and CMD progression.
Authors
- Zelin Chen (ORCID: https://orcid.org/0000-0002-9726-0161)
- Yuanyuan Lin (ORCID: https://orcid.org/0000-0003-4163-0191)
- Kaiyi Zhu (ORCID: https://orcid.org/0000-0002-0727-6996)
- Yuping Gao (ORCID: https://orcid.org/0000-0002-9500-2361)
- Yuchen Cao (ORCID: https://orcid.org/0000-0002-2186-3943)
- Zitong Yuan (ORCID: https://orcid.org/0000-0002-2279-3975)
- Rong Fan (ORCID: https://orcid.org/0000-0002-3388-0847)
- Hao Li (ORCID: https://orcid.org/0000-0001-9426-9446)
- Yuan Jia (ORCID: https://orcid.org/0000-0002-7928-3917)
- Lin Ni
- Luqun Yang
Institutions
- Shanxi Medical University (CN)
- Xian Central Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12967-025-07048-3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation