Haemodynamic Effects of Istaroxime in SCAI Stage B HF-Related Cardiogenic Shock: Insights from the SEISMiC Trial
In patients with ADHF-pre-CS, istaroxime at doses up to 1.0 μg/kg/min for up to 60 h was associated with sustained improvements in measures of LV performance (API and LVSWI), in parallel with increase in PA compliance and reduction in PA elastance at 48 h. As compared with placebo, istaroxime improved LV contractility and preserved RV contractility, which deteriorated on placebo, over time.
Authors
- Agnieszka Tycińska (ORCID: https://orcid.org/0000-0001-7855-7261)
- Koji Takagi (ORCID: https://orcid.org/0000-0003-0213-1509)
- Marianela Barros
- Piotr Gajewski (ORCID: https://orcid.org/0000-0001-6013-5167)
- Gaurav Gulati (ORCID: https://orcid.org/0000-0002-7701-0878)
- Gerasimos S Filippatos (ORCID: https://orcid.org/0000-0002-5640-0332)
- Maria Novosadova
- Chris Edwards (ORCID: https://orcid.org/0000-0002-0585-2697)
- Daniel Burkhoff (ORCID: https://orcid.org/0000-0003-3995-2466)
- Carlos Guardia
- Marı́a Luz Dı́az (ORCID: https://orcid.org/0000-0002-3743-078X)
- Ovidiu Chioncel (ORCID: https://orcid.org/0000-0002-3197-3628)
- Gad Cotter (ORCID: https://orcid.org/0000-0002-9613-3339)
- Steven G. Simonson
- Jan Biegus (ORCID: https://orcid.org/0000-0001-9977-7722)
- Robert Zymliński (ORCID: https://orcid.org/0000-0003-1483-7381)
- Matteo Pagnesi (ORCID: https://orcid.org/0000-0002-9298-7871)
- Alexander Mebazaa
- Beth Davison
- Piotr Ponikowski
- Marco Metra
- Phillip Simmons
Institutions
- Délégation Paris 5 (FR)
- Tufts Medical Center (US)
- Medical University of Białystok (PL)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- Carol Davila University of Medicine and Pharmacy (RO)
- National and Kapodistrian University of Athens (GR)
- Université Paris Cité (FR)
- Wroclaw Medical University (PL)
- Institutul de Urgenţă pentru Boli Cardiovasculare "Prof.Dr. C.C. Iliescu" (RO)
- Assistance Publique – Hôpitaux de Paris (FR)
- Intensive Care Society (GB)
- Surgical Specialties (Canada) (CA)
- Hôpital Lariboisière (FR)
- Windtree Therapeutics (United States) (US)
- Momentum Research (US)
- Estudios Clínicos Latinoamérica (AR)
- Cardiovascular Research Foundation (US)
- Instituto Cardiovascular de Rosario (AR)
- University of Brescia (IT)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1002/ehf2.15448
- Citations
- 1
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.67