Silymarin-functionalized nanohydroxyapatite-chitosan nanocomposite: a promising biomaterial for oral health applications
The silymarin-chitosan-nanohydroxyapatite nanocomposite synthesized using green methods demonstrated high crystallinity, improved wettability, excellent biocompatibility, and multifunctional bioactivity, including antioxidant, antibacterial, and anti-inflammatory effects. The ability of the nanocomposite to support cell migration, inhibit oral pathogens, enhance surface hydrophilicity, and stabilize cell membranes suggests its potential application in oral health, particularly in bone regeneration, periodontal therapy, and inflammation management.
Authors
- Mohammad Ali Shariati (ORCID: https://orcid.org/0000-0001-9376-5771)
- Aravind Kumar Subramanian (ORCID: https://orcid.org/0000-0003-3870-8904)
- Gautham Sivamurthy (ORCID: https://orcid.org/0000-0003-2481-8862)
- R.A. Saleh (ORCID: https://orcid.org/0000-0003-4427-249X)
- Ammar M. AL-Farga (ORCID: https://orcid.org/0000-0002-0233-5539)
- Karen Sarkisovich Karapetyan
Institutions
- University of Dundee (GB)
- University of Jeddah (SA)
- Kazakh Institute of Oncology and Radiology (KZ)
- Kazakh Research Institute of Agriculture and Plant growing (KZ)
- Ibb University (YE)
- Saveetha University (IN)
- Yaroslav-the-Wise Novgorod State University (RU)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12903-025-06784-8
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Saveetha Dental College