Allostatic load and kidney cancer incidence and mortality: a genetic susceptibility and proteomic mediation analysis
AL is associated with increased KC incidence and mortality, mediated through inflammatory and metabolic proteins. These findings underscore chronic physiological stress as a significant factor in KC pathogenesis, providing potential biomarkers for early risk assessment and targeted prevention.
Authors
- Jiayu Liang
- Junjie Zhao (ORCID: https://orcid.org/0000-0002-3696-8991)
- Yanxu Liu (ORCID: https://orcid.org/0000-0002-3571-1932)
- Da Huo (ORCID: https://orcid.org/0000-0002-1378-5033)
- Qiyu Zhu (ORCID: https://orcid.org/0000-0002-2904-7019)
- Chenhao Xu (ORCID: https://orcid.org/0000-0002-1489-1970)
- Xianding Wang (ORCID: https://orcid.org/0000-0003-0113-0395)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12885-025-14980-6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University