Genome-wide Association Analysis for Organ Failure in Acute Pancreatitis
We performed a GWAS examining organ failure in AP and identified 9 candidate loci, which did not pass the genome-wide significance threshold. Three candidate genes, CHD9 , FYB , and MMADHC , were identified through eQTL and differential gene expression analyses. These may represent novel therapeutic targets for organ failure in AP.
Authors
- Carlos F. Fernandez-del Castillo (ORCID: https://orcid.org/0000-0001-5975-7225)
- Casey M. Luckhurst (ORCID: https://orcid.org/0000-0002-7154-8896)
- Katherine Albutt (ORCID: https://orcid.org/0000-0003-1735-7316)
- Mathias A. Christensen (ORCID: https://orcid.org/0000-0001-7438-8114)
- Apostolos Gaitanidis (ORCID: https://orcid.org/0000-0003-3045-5252)
- George C. Velmahos (ORCID: https://orcid.org/0000-0001-5459-0374)
- Yasmin G. Hernandez‐Barco (ORCID: https://orcid.org/0000-0003-1266-3218)
- Peter J. Fagenholz
Institutions
- Harvard University (US)
- Eastern Virginia Medical School (US)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Pancreas
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1097/mpa.0000000000002581
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00