USP43 promotes cerebral ischemia–reperfusion injury via activation of TAK1
These results suggest that USP43 promotes I-R damage by activating TAK1 and its downstream signaling pathways. Inhibition of USP43 may be a potential treatment modality for acute stroke.
Authors
- Weiyu Sun
- Tingbao Zhang (ORCID: https://orcid.org/0000-0001-9758-9998)
- Feng Yu (ORCID: https://orcid.org/0000-0002-5991-9981)
- Sha Hu (ORCID: https://orcid.org/0000-0002-0114-7982)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-1792-3130)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-6449-8379)
- Wenyuan Zhao (ORCID: https://orcid.org/0000-0002-8125-711X)
- Yuhan Dong (ORCID: https://orcid.org/0000-0001-5275-1787)
- Jincao Chen (ORCID: https://orcid.org/0000-0003-4608-9736)
Institutions
- Wuhan University (CN)
- Wuhan College (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13578-025-01475-x
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00