Fusobacterium in the microbiome: from health to disease across the oral–gut axis and beyond
Fusobacterium functions as both commensal and pathogen, linking the oral-gut axis to diverse diseases, including cancer. Evidence shows it modulates microbial balance, promotes dysbiosis, and contributes to carcinogenesis by driving inflammation, proliferation, invasion, and immune evasion. This review integrates ecological, molecular, and clinical insights, highlighting its roles in oral and systemic disease and discussing therapeutic potential, underscoring Fusobacterium's dualistic nature and implications for microbiome-targeted interventions.
Authors
- Xufeng Huang (ORCID: https://orcid.org/0000-0001-9941-3355)
- Divya Gopinath (ORCID: https://orcid.org/0000-0002-4279-7420)
- Zhengrui Li (ORCID: https://orcid.org/0000-0003-4923-0088)
- Dan Shan (ORCID: https://orcid.org/0000-0002-2762-6770)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Jian Liu (ORCID: https://orcid.org/0000-0002-1447-0973)
- Jing Li (ORCID: https://orcid.org/0000-0002-8840-8638)
- Peng Luo (ORCID: https://orcid.org/0000-0002-8215-2045)
- Zhaokai Zhou
Institutions
- University of Debrecen (HU)
- Central South University (CN)
- Ajman University (AE)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Zhujiang Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Shanghai Clinical Research Center (CN)
- Southern Medical University (CN)
- Lancaster University (GB)
Publication Details
- Journal
- npj Biofilms and Microbiomes
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1038/s41522-025-00838-z
- Citations
- 10
- Primary Topic
- Otolaryngology and Infectious Diseases
- Type
- article
- Field-Weighted Citation Impact
- 13.96