Zinc finger protein Zfp335 is required for T cell homeostatic proliferation through regulating Lmnb1
Our results reveal a previously unrecognized role of Zfp335 in maintaining T cell homeostasis within peripheral lymphoid tissues. Specifically, Zfp335 promotes the homeostatic proliferation of naïve T cells by directly modulating the expression of the Lmnb1 gene which ensuring the capacity of immune system.
Authors
- Xiaofeng Yang (ORCID: https://orcid.org/0000-0002-2832-0597)
- Jun O. Liu (ORCID: https://orcid.org/0000-0003-3842-9841)
- Yuying Ren (ORCID: https://orcid.org/0000-0002-9566-2116)
- Xiaobo Zhou (ORCID: https://orcid.org/0000-0002-7127-2869)
- Biao Yang (ORCID: https://orcid.org/0000-0002-6002-3330)
- Peng R. Chen (ORCID: https://orcid.org/0000-0002-0402-7417)
- Haiyan Liu (ORCID: https://orcid.org/0000-0003-3158-0661)
- Tianzhe Zhang (ORCID: https://orcid.org/0000-0002-7114-3573)
- Wenhua Li (ORCID: https://orcid.org/0009-0001-7517-2363)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-2187-5952)
- Xin Wang (ORCID: https://orcid.org/0000-0001-8051-1481)
- Lei Lei (ORCID: https://orcid.org/0000-0002-7506-2180)
- Jiapeng Song
- Baojun Zhang (ORCID: https://orcid.org/0000-0002-7786-4304)
- Yang Gao (ORCID: https://orcid.org/0000-0002-4723-4416)
- Ning Yuan (ORCID: https://orcid.org/0000-0002-1839-8622)
Institutions
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Xi'an Medical University (CN)
- First Hospital of China Medical University (CN)
- Xi'an Jiaotong University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13578-025-01483-x
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China