Safety of antipyretic therapy in pediatric practice as the basis for choosing a drug: A review

For many years, doctors and patients have been concerned about drug safety due to the need to use highly effective drugs and minimize adverse effects. The establishment of pharmacovigilance systems has a century-long history, marked by tragic events that led to reforms in drug safety. Modern medicine is characterized by the rapid development and introduction of innovative technologies into clinical practice, which still dictates the need to control the profile of the effectiveness and safety of drugs. In pediatric practice, fever is the most common symptom and the primary reason for outpatient pediatrician visits. Understanding the pathogenesis of fever helps to prescribe antipyretic agents more reasonably. Paracetamol and ibuprofen meet the basic requirements; they have proven safety and efficacy. However, cases of antipyretic drug poisoning are still reported all over the world, which emphasizes the need to optimize approaches to their use in children. One of them is the use of combination drugs, which offer higher clinical effectiveness and a high safety profile.