Reversal of tumour immune evasion via enhanced MHC-Class-I antigen presentation by a dual-functional RNA regulated system
The present study successfully engineered a dual-functional RNA-regulated system that augments tumour cell antigen presentation and reconfigures the immune landscape within the TME, thereby potentiating the anti-tumour efficacy of the mRNA vaccine.
Authors
- Zhen Gu (ORCID: https://orcid.org/0000-0003-2947-4456)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-7130-3215)
- Yan Xu (ORCID: https://orcid.org/0000-0002-2832-2664)
- Gangcheng Kong (ORCID: https://orcid.org/0000-0002-1581-8257)
- Jianxiang Chen (ORCID: https://orcid.org/0000-0002-8193-191X)
- Jiaying Cao (ORCID: https://orcid.org/0009-0009-0365-3123)
- Hongjun Li (ORCID: https://orcid.org/0000-0002-1765-8445)
- Xuewen Yi
- Shusen Zheng (ORCID: https://orcid.org/0000-0002-9003-3142)
- Xiaoge Zhang (ORCID: https://orcid.org/0000-0001-7991-8516)
- Chaoyang Meng
- Ling Qi (ORCID: https://orcid.org/0009-0005-0301-0823)
- Huipeng Zhang (ORCID: https://orcid.org/0009-0002-5328-2489)
- Huiheng Feng
- Haoxiang Qi (ORCID: https://orcid.org/0009-0002-8417-3832)
- Xiaohan Lin
- Qing Wu
- Bei Wang
Institutions
- Sir Run Run Shaw Hospital (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- National Center for Infectious Diseases (US)
- Ministry of Public Health (MG)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12943-025-02480-x
- Citations
- 6
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 4.78