KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
KDM6A and KDM6B mediate critical mechanisms behind EWSR1::FLI1 transcriptional activation program involving demethylase-independent and dependent functions, respectively, supporting the development of therapeutic strategies targeting these demethylases in Ewing sarcoma.
Authors
- Elisabet Figuerola-Bou (ORCID: https://orcid.org/0000-0002-6839-9586)
- Sara Pérez‐Jaume (ORCID: https://orcid.org/0000-0002-9805-4810)
- Nicolò Riggi (ORCID: https://orcid.org/0000-0001-9160-1984)
- Marta García (ORCID: https://orcid.org/0000-0002-7030-1680)
- Pablo Táboas (ORCID: https://orcid.org/0000-0003-4972-677X)
- María Sánchez-Jiménez (ORCID: https://orcid.org/0000-0003-4214-6297)
- Sara Sánchez-Molina (ORCID: https://orcid.org/0000-0002-1430-131X)
- Luciano Di Croce (ORCID: https://orcid.org/0000-0003-3488-6228)
- Enrique Blanco (ORCID: https://orcid.org/0000-0001-6261-7370)
- Cinzia Lavarino (ORCID: https://orcid.org/0000-0002-9630-3676)
- Carla Ríos-Astorch (ORCID: https://orcid.org/0000-0002-5856-359X)
- Guerau Fernández (ORCID: https://orcid.org/0000-0003-2987-9971)
- Soledad Gómez‐González (ORCID: https://orcid.org/0000-0002-0578-4276)
- Pol Castellano‐Escuder (ORCID: https://orcid.org/0000-0001-6466-877X)
- Alexandra Avgustinova (ORCID: https://orcid.org/0000-0001-6016-2931)
- Jaume Mora (ORCID: https://orcid.org/0000-0002-9386-5980)
- Estela Prada (ORCID: https://orcid.org/0000-0003-4611-1120)
- Silvia Mateo‐Lozano (ORCID: https://orcid.org/0000-0002-2365-1573)
- Oscar Muñoz (ORCID: https://orcid.org/0009-0000-9888-0242)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Hospital Sant Joan de Déu Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- Centre Hospitalier Universitaire Vaudois (CH)
- Tissue Gene (United States) (US)
- Institute for Research in Biomedicine (ES)
- Sant Joan de Déu Research Foundation (ES)
- Intermolecular (United States) (US)
- Centre for Genomic Regulation (ES)
- Institut de Recerca Sant Joan de Déu
- Universitat de Barcelona (ES)
- University of Lausanne (CH)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3452
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52