KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma

KDM6A and KDM6B mediate critical mechanisms behind EWSR1::FLI1 transcriptional activation program involving demethylase-independent and dependent functions, respectively, supporting the development of therapeutic strategies targeting these demethylases in Ewing sarcoma.

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Publication Details

Journal
Cancer Research
Published
2025-10-14
DOI
https://doi.org/10.1158/0008-5472.can-24-3452
Citations
1
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.52
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article

KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma

Elisabet Figuerola-Bou, Sara Pérez‐Jaume, Nicolò Riggi, Marta García et al.
1 citations
Cancer Research
Sarcoma Diagnosis and Treatment
1.52
article

KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma

Elisabet Figuerola-Bou, Sara Pérez‐Jaume, Nicolò Riggi, Marta García, Pablo Táboas, María Sánchez-Jiménez, Sara Sánchez-Molina, Luciano Di Croce, Enrique Blanco, Cinzia Lavarino, Carla Ríos-Astorch, Guerau Fernández, Soledad Gómez‐González, Pol Castellano‐Escuder, Alexandra Avgustinova, Jaume Mora, Estela Prada, Silvia Mateo‐Lozano, Oscar Muñoz
article en
1 citations

Abstract

KDM6A and KDM6B mediate critical mechanisms behind EWSR1::FLI1 transcriptional activation program involving demethylase-independent and dependent functions, respectively, supporting the development of therapeutic strategies targeting these demethylases in Ewing sarcoma.

Cancer ResearchVol. 85(22)
Institució Catalana de Recerca i Estudis Avançats (ES), Hospital Sant Joan de Déu Barcelona (ES), Universitat Pompeu Fabra (ES), Centre Hospitalier Universitaire Vaudois (CH), Tissue Gene (United States) (US), Institute for Research in Biomedicine (ES), Sant Joan de Déu Research Foundation (ES), Intermolecular (United States) (US), Centre for Genomic Regulation (ES), Institut de Recerca Sant Joan de Déu, Universitat de Barcelona (ES), University of Lausanne (CH)
Openalex Percentile: Top 14%
Sarcoma Diagnosis and Treatment
1.52
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