H2BC9 lactylation modulates esophageal squamous cell carcinoma progression via the Wnt/β-catenin signaling pathway
Our study reveals a novel regulatory axis in which H2BC9 K44 lactylation activates Wnt7b transcription and downstream Wnt/β-catenin signaling, driving ESCC progression. Targeting H2BC9 lactylation may offer a promising therapeutic strategy to overcome tumor growth and immune evasion in ESCC.
Authors
- Lansheng Zhang (ORCID: https://orcid.org/0000-0003-2772-3797)
- Keke Xia
- Yun Zhou (ORCID: https://orcid.org/0000-0003-1552-9727)
- Jie Mou (ORCID: https://orcid.org/0000-0002-0952-4500)
- Dong‐Sheng Pei (ORCID: https://orcid.org/0000-0002-8053-3741)
- Jing Zhu (ORCID: https://orcid.org/0000-0001-8893-9888)
- Ce Shi (ORCID: https://orcid.org/0000-0002-7828-2728)
- Lin Wang (ORCID: https://orcid.org/0000-0002-7215-8750)
- Yuxiang Zhang (ORCID: https://orcid.org/0000-0002-2380-6977)
- Shuling Wang
Institutions
- Xuzhou Medical College (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12967-025-07144-4
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Xuzhou Medical University