Cell line-specific estrogen responses uncover functional sex differences in murine macrophages
These findings underscore the importance of accounting for both the origin of immune cells as well as the hormonal and environmental context in which they are studied. Without these considerations, experimental models risk missing critical biological differences that shape immune responses and disease outcomes.
Authors
- Nana Owusu‐Boaitey (ORCID: https://orcid.org/0000-0003-0974-6346)
- Erika Moore (ORCID: https://orcid.org/0000-0003-2192-6147)
- Alison M. Veintimilla (ORCID: https://orcid.org/0009-0003-4648-7539)
- Margaret M. McCarthy (ORCID: https://orcid.org/0000-0003-2243-4726)
- Vikram Deshpande (ORCID: https://orcid.org/0000-0003-4230-9308)
- Zachary S. Turner
Institutions
- University of Maryland, Baltimore (US)
- Park University (US)
- University of Maryland, College Park (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13293-025-00760-1
- Citations
- 3
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Lupus Research Alliance
- National Institute of General Medical Sciences