KBTBD11 suppresses hepatocellular carcinoma by targeting ENO1-mediated glycolysis
These findings identify KBTBD11 as a negative regulator of ENO1-mediated glycolysis in HCC. By promoting ENO1 degradation, KBTBD11 links ubiquitin signaling to metabolic control and tumor suppression, highlighting a potential therapeutic target for metabolically active liver cancer.
Authors
- Xiandong Lin (ORCID: https://orcid.org/0000-0002-3250-4014)
- Jinluan Li (ORCID: https://orcid.org/0000-0002-3533-898X)
- Hanshen Chen
- Feifei Lin (ORCID: https://orcid.org/0009-0008-8525-1955)
- Yixuan Liu (ORCID: https://orcid.org/0009-0005-1480-5744)
- Yiran Chen (ORCID: https://orcid.org/0000-0002-4602-2454)
- Lirui Tang (ORCID: https://orcid.org/0000-0002-9863-3732)
- Qingyang Zhuang
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12967-025-07161-3
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94