Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression
This study first characterized the gut microbiota architecture in adolescent BD. Combining gut microbiota and brain function biomarkers may benefit disease diagnosis and predict treatment outcome. Nonetheless, these findings should be carefully interpreted considering the limitations of a modest sample size and the absence of detailed mechanistic explorations. Trial registration NCT05480150. Registered 29 July 2022-Retrospectively registered, https://clinicaltrials.gov/study/NCT05480150 .
Authors
- Jiahong Ding
- Jianbo Lai (ORCID: https://orcid.org/0000-0002-8137-7701)
- Anying Tang
- Yi Chen (ORCID: https://orcid.org/0000-0002-8640-967X)
- Zhiming Li (ORCID: https://orcid.org/0000-0001-5589-1136)
- Shaohua Hu (ORCID: https://orcid.org/0000-0003-1858-8028)
- Chenggang Xu (ORCID: https://orcid.org/0000-0002-1343-8963)
Institutions
- BGI Group (China) (CN)
- Allen Institute for Brain Science (US)
- Fudan University (CN)
- Zhejiang Lab (CN)
- Zhejiang University-University of Edinburgh Institute (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12967-025-07152-4
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities