Mitochondrial ribosomal protein L12 mediates metabolic reorganization in clear cell renal cell carcinoma by regulating mitochondrial biosynthesis
Our study reveals that MRPL12 regulates mitochondrial metabolism to inhibit ccRCC cell proliferation, migration, and invasion, suggesting that targeting MRPL12 may represent a promising therapeutic strategy for ccRCC.
Authors
- Qiang Wan (ORCID: https://orcid.org/0000-0001-9173-2941)
- Dun Su (ORCID: https://orcid.org/0000-0002-8342-521X)
- Shicong Lu
- Lingju Chu
- Bo Wang (ORCID: https://orcid.org/0000-0001-9234-035X)
- Tianyi Dong
- Tianyi Zhang (ORCID: https://orcid.org/0000-0002-2833-3363)
- Xiaoming Sun (ORCID: https://orcid.org/0000-0003-0375-0563)
- Shengnan Sun (ORCID: https://orcid.org/0000-0003-2494-5327)
- Yi Liu (ORCID: https://orcid.org/0000-0002-2207-8074)
- Xingzhao Ji
Institutions
- Jinan Central Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12964-025-02375-w
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Shandong First Medical University